To the Moon

That night, Johnny gives River a toy platypus which River treasures for the rest of her life. Shortly after, Johnny's twin brother Joey was killed in an accident.

Johnny's mother gave him beta blockers to induce memory loss of the tragic event, also causing him to forget his first encounter with River. He later happened to meet her again, and eventually marry her, and River only realized later on that he had forgot their meeting at the carnival.

(Johnny confessed that he approached her in school because she was different, and revealed that he thought that was their first meeting) River, diagnosed as an adult with Asperger syndrome (although never directly stated, the game references Tony Attwood, who wrote numerous books about Aspergers), did not tell Johnny directly about their first meeting; instead, she tried to indirectly jostle his memories by cutting her hair and crafting paper bunnies, including a dual-colored one representing the constellation they made up during their first encounter, combined with the blue-and-yellow dress she wore on their wedding. River was unable to make Johnny remember before she died, and Johnny was left with lingering guilt and an inexplicable desire to go to the Moon.

In the present, Rosalene and Watts eventually implant a memory sequence in which Joey did not die, and lived on to become a popular author, and Johnny did not meet River again until they started working together at NASA. As the comatose real-life Johnny begins to die, he imagines going on a moon mission with River.

During the launch, River holds out a hand to him. The moon appears through a window on the ship, and Johnny takes her hand as his heart monitor flatlines.

In the epilogue, Johnny and River eventually get married, and build and retire to the same house where the real-life Johnny and River lived. Back in the real world, Rosalene and Watts look to Johnny's grave, which is placed adjacent to River’s.

They reveal to the audience that Johnny willed the house to his caregiver, Lily. Rosalene receives a phone call, and the two move on to their next patient.

While Watts is leaving, he stops and the screen briefly flashes red, the same way it did when Johnny felt pain. Watts takes some painkillers, then continues onward.